Document Type : Original Article
Author
Department of Biology / College of science for women/ Baghdad University /Baghdad ,Iraq
Abstract
The study aimed to evaluate the effects of different doses of gabapentin on the testes and epididymis of adult male mice and on oxidative stress markers, it also investigated its impact on sperm quality and overall reproductive function . Twenty-four adult male mice were randomly divided into 4 groups. Mice of groups 1 served as control and administrated with 0.1 ml sterile saline, and other groups treated with Gabapentin orally administered with 0.1 ml of a daily dose of concentrations (5, 10, 20) mg/kg for 60 consecutive days. Gabapentin significantly decrease (p < 0.05) the absolute weight of body, testis and tail of epididymis of treated mice, significantly increased (P≤ 0.05) malondialdehyde serum level , catalase and superoxide dismutase, also show significantly decreased (P≤0.05) in glutathione levels and vitamin E levels . The results observe several histological changes in the testes and cauda of epididymis includes, azoospermia, Detaching spermatogonia, Necrosis, Edema, Congestion, Amyloid deposition , Irregular tubule , Rupture of seminiferous tubules epithelium , Slephing germ cells , Atrophy Tubules, Shrinkage tubule, Hemorrhagic , Hyperplasia, and Pyknosis. The sperm of mice treated with the drug at its three concentrations showed several abnormalities., including coiled , folded and broken tails, bent neck, , tailless, as well as sperms with cytoplasmic droplets. Gabapentin administration negatively affects the testes and epididymis ,impairing sperms quality and overall reproductive function in mice .These findings suggest that long-term gabapentin use may pose risks to male fertility .
Keywords
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