Document Type : Original Article
Authors
1 Iraqi Ministry of Education, General Directorate of Education in Basra Governorate, Iraq
2 Department of Chemistry, College of Education for Pure Science, University of Basrah, Basrah, Iraq; b Department of Physics, College of Education for Pure Science, University of Basrah, Basrah, Iraq
3 Department of Medical Laboratory Technology, College of Health and Medical Technology, Alkunooz University, Basra, Iraq
Abstract
The study included the preparation of three types of chalcons compound (T1, T2, and T3) through the interaction of addition (4-azidophenylethanone) with some types of aldehydes (oxochromane-3-carbldehyde , 4-dimethyl ameno benzaldehyde,3-nitro benzaldehyde) With the presence of a basic medium, the prepared compounds were diagnosed with FTIR infrared technology, 1H-NMR technology, 13C-NMR, and by the Mass-spectra technique that was used in the diagnosis of the prepared compounds. Good results. The effectiveness of these compounds against oxidative stress was studied on the cell line HCAM and good results were shown, The prepared azide compounds were loaded on liposomes which were prepared from lecithin, The effect of the acidic function on the liberation of the prepared compounds from the layers of lipid nanoparticles was also studied at the functions (pH = 7.2), stomach fluid (pH = 1.2) and intestines (pH = 8.2) and using ultraviolet spectroscopy at a temperature of (37°C). The effectiveness of the liposomes loaded against human liver cancer HCAM and the rate of inhibition at a concentration of 1000 micrograms/mol were measured and the lethal half concentration IC50 was calculated using different concentrations (10,100,200,500,750) micrograms/mol and in the presence of DMSO solvent, and they showed good results and high efficacy. The comparison was also made using a TEM electron microscope of the liposomes in the presence and absence of the prepared compounds.
Keywords
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