Document Type : Original Article
Author
Abstract
Newly diagnosed type 2 diabetic patients show varied metabolic profiles influenced
by factors like age, sex, and body mass index, which affect disease progression and risk of other
health problems. To evaluate how demographic factors such as age, sex, and body mass index
(BMI) influence glycemic control and lipid profile parameters in patients newly diagnosed with
type 2 diabetes mellitus. The study included 60 newly diagnosed type 2 diabetic patients aged 30
to 75 years. Blood samples were collected after overnight fasting; they were divided into two parts,
with the EDTA tube used immediately for HbA1c measurement, while the other parts were
separated to obtain serum for biochemical parameters. Biochemical measurements included
glucose and lipid profile by enzymatic methods, HbA1c by ion exchange HPLC, and insulin by
sandwich electrochemiluminescence immunoassay. Insulin resistance was calculated using the
HOMA-IR formula. Biochemical parameters were not varied significantly by age or sex except
for higher total cholesterol and HDL cholesterol in females. Obesity was strongly associated with
increased insulin resistance and an adverse lipid profile characterized by elevated TG, VLDL
cholesterol, LDL cholesterol, and reduced HDL cholesterol. Glycemic control markers (glucose,
HbA1c) were not significantly linked to lipid abnormalities. This study concluded that age and sex
do not affect glycemic control and lipid profile, except that women have higher total cholesterol
and HDL cholesterol. However, obesity is strongly associated with increased insulin resistance and
an adverse lipid profile.
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