Document Type : Original Article
Author
Abstract
Amebiasis, caused by Entamoeba histolytica, is a significant global health issue, particularly in
regions with poor sanitation. Nitric oxide, an adaptable signaling molecule, plays a complex role in
this infection. While NO can contribute to tissue destruction and inflammation, it also exhibits
protective properties by aiding in wound healing and inhibiting parasite proliferation. Thus, NO's
impact on amebiasis involves a delicate balance of harmful and useful effects. This study aimed to
determine the relationships between age, Entamoeba histolytica infection, and nitric oxide levels in
infected patients. This case-control study, conducted in Al-Najaf, Iraq, from September 2024 to
January 2025, investigated nitric oxide levels in 50 confirmed Entamoeba histolytica infection
cases by examining serum samples collected from patients at multiple hospitals. Serum samples
were obtained and stored at -80°C for nitric oxide analysis. The study indicated that E. histolytica
infection was most frequent among individuals aged 21-40 years. Additionally, a notable rise in
nitric oxide levels was observed in infected patients between 31 and 49 years old. In conclusion,
this study suggests Infection was most common in 21-40 year olds, while NO levels were
significantly elevated in infected individuals aged 31-49.
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