Document Type : Original Article
Author
Abstract
To allow poultry to be produced with good producibility and safety with high-quality products,
the avian immune system is essential. Vaccinations, feed supplements, and other treatments have
been shown to improve innate immunity in a variety of animals throughout the last ten years. Based
on this study, it is demonstrated whether synthetic IgY might effectively induce trained innate
immunity in chickens to improve their defense mechanisms against viral infection. This study
made use of 120 one-day-old chicks and assigned them to six categories; G1, chicks were given
only natural ration and water; G2, chicks were treated with ND vaccine; Groups 3,4, and 5 were
treated with IgY orally, IM, and SQ respectively; G6, chicks were treated orally by IgY+ND
vaccine, all treatment done at 12th days old, after 3 weeks the blood has been collected and
Hemagglutination inhibitions (HI) test performed for all chicks’ groups. The body weight
significantly (P≤0.5) increased in week one and week two in groups that received IgY orally and
synergistic group vs. the other group, while in week three, all groups that received IgY, more
specifically oral route showed highly significant (P≤0.5) increasing vs. to the other groups. The
IgY increased immunity in chicks after each challenge significantly vs. the other groups including
the ND vaccine group, followed by the synergistic group also showed a peak in immunity (P≤0.5).
According to the study, broiler chicks given chicken IgY had higher HI titters and higher protection
rates, and the oral IgY produced better outcomes.
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