Document Type : Original Article
Author
Abstract
Background: Evaluation of the level of trace minerals in blood serum is one of the important
things that can give us evidence of acute kidney injury, as the high concentrations of some
trace minerals such as (Iron, lead, Cadmium, and Copper) and low concentrations of other
minerals such as (zinc) in the blood serum are considered one of the Evidence of acute kidney
injury, Objective: is to try to Prove that increasing the Concentrations of Some trace
minerals can Cause nephrotoxicity and acute kidney failure, while their Presence in normal
proportions in blood serum is beneficial to the human body as antioxidants or Cofactor.
Methods and Material: This cross-sectional study was conducted in (Ibn Sina, Al-Salam,
and Al-Jumhuri) Teaching Hospitals and the Central Blood Bank in Mosul, Iraq. Between the
period (May 2022 - February 2023), where the study included 124 blood samples collected
from men and women who suffer from acute Kidney injury and 108 blood samples collected
from control groups, whose ages ranged from (≤35-≥56 years). The levels of Iron, Lead,
Cadmium, Zinc, and Copper were determined in the blood serum of both acute kidney injury
patients and the control group by atomic absorption spectroscopy technique. Results: The
results indicated a significant increase in the level of (Iron, Lead, Cadmium and Copper) at (P
≤ 0.05) compared to the control group, while a significant decrease in the level of Zinc at the
probability level (p≤0.05) compared to the control group. Conclusion: We conclude, through
our study, that the decrease in the concentration of Zinc in acute kidney injury patients is
matched by an increase in the concentration of Copper on the other hand, while an increase in
the concentration of minerals (Iron, Lead and Cadmium) occurs in acute kidney injury
patients as a result of the accumulation of these minerals in the kidney after reaching toxicity
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