Document Type : Original Article
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Abstract
Background: Chronic hyperglycaemia, also known as high blood glucose, is a metabolic disorder that develops when the body cannot produce enough insulin or when its response to insulin is compromised. Insulin is a crucial hormone that plays a vital role in carbohydrate, lipid, and protein metabolism. The current study aimed to investigate the potential associations between osteonectin with zinc ions (Zn+2), sodium ions (Na+), potassium ions (K+), chloride ions (Cl-), systolic blood pressure (SBP), blood pressure during diastole (DBP) and glucose levels in the blood while fasting in people who have type 2 diabetes mellitus (T2DM). Materials and Methods: This research involved 42 patients from Al-Ramadi Teaching Hospital, along with 42 apparently seems healthy controls (HCs). Zn+2 and osteonectin levels in the serum were measured using the enzyme-linked immunosorbent assay (ELISA). Serum levels of Na+, K+ and Cl- levels were estimated using the C4000 device. Results: Serum osteonectin (µg/mL) in T2DM patients was higher than in controls (P < 0.0001), while Zn+2, K+, Cl-, SBP, DBP in T2DM patents were lower than controls. A significant positive correlation was detected between osteonectin with K+ but, a non-significant positive correlation of osteonectin with Na+, SBP, DBP, and mean arterial blood pressure (MAP) was detected, osteonectin showed a strong inverse relationship with Cl- and Zn+2, according to the findings. Rreceiver operating characteristic (ROC) curve indicate that osteonectin was weaker sensitive marker in diagnosis of T2DM. in addition, SBP, MAP are intermediate markers, while osteonectin, Na+, K+, Cl-, Zn+2 , and DBP were markers with poor predictive values, with area under curve (AUC) gave less than 0.6. Conclusion : Patients' serum osteonectin levels were greater than those of healthy controls were. osteonectin also showed weak correlations with zinc and the other variables studied, and the best correlation for osteonectin was with sodium ions.
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